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Tryptophan is another food source of niacin because this amino acid—when present in amounts beyond that required for protein synthesis—can be converted to NAD, mainly in the liver [ 3, 5]. The most commonly used estimate of efficiency for tryptophan conversion to NAD is 1:60 (i.e., 1 mg niacin [NAD] from 60 mg tryptophan). Turkey is an example of a food high in tryptophan; a 3-oz portion of turkey breast meat provides about 180 mg tryptophan, which could be equivalent to 3 mg niacin [ 9]. However, the efficiency of the conversion of tryptophan to NAD varies considerably in different people [ 3]. Niacin is known to be used for the clinical therapy of atherosclerosis. Studies to date have pointed toward niacin’s ability to reduce hardening of the arteries, also known as atherosclerosis, for some people. As discussed in one scientific review, niacin has been shown to selectively increase the plasma levels of Lp-AI, a component of HDL that has a cardio-protective effect in patients with low HDL levels. ( 8) In addition, niacin supplementation has been shown to significantly decrease oxidative stress, which is known to contribute to atherosclerosis. ( 9, 10)
By some reports, virtually every person who takes high doses of nicotinic acid experiences flush ( 6). The study included 17 patients with hypercholesterolemia (high cholesterol) and low HDL cholesterol along with eight healthy control subjects. Overall, the study found that niacin supplementation decreased oxidative stress and triglyceride levels while significantly increasing HDL levels in the high cholesterol subjects. ( 6) 2. Can Increase Good Cholesterol Banka, S. S., et al. (2017). Randomized controlled trial of different aspirin regimens for reduction of niacin-induced flushing [Abstract]. Niacin is available in multivitamin/mineral products, in supplements containing other B-complex vitamins, and in supplements containing niacin only. Nicotinic acid and nicotinamide are the two most common forms of niacin in supplements. Some niacin-only supplements contain 500 mg or more per serving, which is much higher than the RDA for this nutrient [ 11].Niacin supplements can interact with medical conditions and drugs. This could lead to poor health and worsen conditions. Anyone with the following issues should take extra precaution before taking niacin: Science suggests that niacin deficiency can cause psychiatric conditions. The brain requires the coenzymes of niacin to function well. Hence, niacin is effective at regulating the brain’s function and the release of neurotransmitters.
Like other B vitamins, niacin is a water-soluble vitamin and must be obtained through food or a supplement. But while there are food sources of niacin, sometimes the best way to ensure your body is getting enough quantities is through dietary supplements.
Do all niacin supplements cause a flush?
As mentioned above, to avoid unwanted symptoms, including flushing, some people opt for extended-release or long-acting niacin. It took decades for the medical community to discover that insufficient levels of vitamin B3 significantly impact cognitive performance, digestive health and skin health. But it wasn't until the mid-1900s that people realized a diet rich in leafy greens, lean protein (poultry, fish, beef and organ meats) and healthy fats like nuts and seeds was key in maintaining healthy niacin levels. This discovery is why many food manufacturers fortified food like breads and cereals with niacin, to help ensure everyone gets this vital B vitamin. Long-acting niacin is associated with significantly reduced flushing, as it’s absorbed over a long time period that typically exceeds 12 hours. Because of this, taking long-acting niacin significantly reduced the chances of flushing ( 11). A niacin flush as well as niacin supplementation is often not recommended for anyone with the following conditions: ( 17)
Niacin (B3; nicotinic acid) oral. Facts & Comparisons eAnswers. http://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed Aug. 9, 2017. Increase HDL (good) cholesterol. It prevents the breakdown of apolipoprotein A1, which is used to make HDL (good) cholesterol. It can increase HDL (good) cholesterol by up to 20–40% ( 1, 12). Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; Common Internet searches for niacin include “niacin flush drug test” and “niacin flush thc.” What’s the story with that? Apparently, some people conduct a niacin flush in an attempt to pass a drug test.to make sure that it is safe for you to take Niacin Flush Free (inositol niacinate) with all of your drugs and health problems. Do not start, stop, or change the dose of WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your
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